Chair(s): Corrado Angelini (Italy)

• Clinical phenotypes and management of patients with hyperCKemia and statin myopathy - Marianne de Visser (Netherlands)
• How to diagnose a patient with hyperCKemia - Sabrina Sacconi (France)
• Metabolic myopathies with hyperCKemia or cramps - Corrado Angelini (Italy)
• Diagnostic approach and guidelines for oligosymptomatic hyperCKemia - Thedore Kyriakides (Cyprus)

Chair(s): William (Bill) Phillips (Australia)

• Introduction to structure & function, mechanisms of NMJ development and effects of autoantibodies - William (Bill) Phillips (Australia)
• Neurophysiology - Clark Slater (UK)
• Presynaptic receptors - Ana Maria Sebastião (Portugal)
• Diseases involving impairment and loss of neuromuscular connections - Hanns Lochmüller (UK)

Chair(s): Michaela Auer-Grumbach (Austria)

• CMT Neuropathies in the elderly - Michaela Auer-Grumbach (Austria)
• Essential clues to early recognition of amyloid neuropathies - Davide Pareyson (Italy)
• Sensory and Autonomic Hereditary Neuropathies - Max Hilz (Germany)
• Neuropathic manifestations in porphyria - James Dyck (USA)

Chair(s): Günther Bernert (Austria) , James Dowling (Canada)

• Introduction: Epidemiology and Differential Diagnosis - Günther Bernert (Austria)
• Clinical Assessment and muscle imaging: techniques and pitfalls - Eugenio Mercuri(Italy)
• The Muscle Biopsy in the “Next-Gen-Era”: snows of yesteryears? - Reginald Bittner (Austria)
• Floppy infant syndrome and the role of “next gen” - James Dowling (Canada)
• What you may miss without EMG - Matthew Pitt (UK)

Chair(s): Wolfgang Löscher (Austria)

• Entrapment syndromes in the upper extremity - Electrophysiology - Christian Bischoff (Germany)
• Entrapment syndromes in the upper extremity - Sonography - Nens van Alfen (Netherlands)
• Entrapment syndromes in the lower extremity - Electrophysiology - Simon Podnar (Slovenia)
• Entrapment syndromes in the lower extremity - Sonography - Alexander Grimm (Germany)

Chair(s): Richard Barohn (USA)

• Pattern recognition approach to muscle disorders - Richard Barohn (USA)
• Laboratory approach to muscle disorders - Mazen Dimachkie (USA)
• Genetic approach to muscle disorders - Tahseen Mozaffar (USA)
• Approach to translational research and clinical trials in muscle disease - Michael Hanna (UK)

Chair(s): Albert Ludolph (Germany)

• How do we discuss the genetic implications with ALS - Ryuji Kaji (Japan)
• Cognitive change – recognition and management - Albert Ludolph (Germany)
• Breaking the news of the diagnosis - Dorothée Lulé (Germany)
• The role of multidisciplinary care in ALS - Christopher McDermott (UK)

Chair(s): TBD

• MRI and US in the diagnosis of neuropathy - Stephan Goedee (Netherlands)
• Skin biopsy: not just for diagnosis - Grazia Devigili (Italy)
• Outcome measures in neuropathy - Ingemar Merkies (Netherlands)
• Role of electrophysiology in the characterization and diagnosis of neuropathies: new insights - Peter Van den Bergh (Belgium)

Chair(s): Volker Straub (UK)

• Introduction - Volker Straub (UK)

• Requirements and pitfalls for small molecules - Mike Kelly (USA)
• Requirements and pitfalls for gene therapy - Isabelle Richard (France)
• Requirements and pitfalls for stem cells - Giulio Cossu (UK)

• Preclinical trial design - Annamaria De Luca (Italy)
• Statistical power evaluation - Heather Gordish-Dressman (USA)
• Data interpretation, translational meaning - Annamaria De Luca (Italy)

• Regulatory requirements - TBD
• Clinical trial readiness - Kathryn Wagner (USA)
• Care aspects in clinical trial planning - Anna Mayhew (UK)
• Patient perspective - Elizabeth Vroom (Netherlands)
• Business model - Cristina Csimma (USA)

Q&A

Chair(s): Walter Struhal, (Austria), Anne Pavy-Le Traon (France), J.G. Van Dijk (Netherlands), G. K. Wenning (Austria)

I) Health and disease
• Chair: Walter Struhal (Austria)
• ANS: the interface between outer and inner world - I. Rocha (Portugal)
• Autonomic disorders: what goes wrong – H. Lahrmann (Austria)

II)Diagnostic tools
• Chair: Anne Pavy-Le Traon (France)
• Cardiovascular autonomic function tests and ABPM – G. Calandra-Buonaura (Italy)
• Neuroendocrine and nuclear autonomic function tests – C. Rocchi (Italy)
• Practical session: how to perform a cardiovascular autonomic function test, Part I – W. Struhal (Austria)

Networking break

III) Bedside approach to ANS disorders
• Chair: J.G. Van Dijk (Netherlands)
• Autonomic history taking: you need to know what you’re looking for – R. Thijs (Netherlands)
• Syncope, pseudosyncope and other orthostatic intolerance syndromes – A. Pavy-Le Traon (France)
• Autonomic syndromes: how to put the pieces of the jigsaw together – E. Lenzenweger (Austria)

IV) Management of ANS disorders
• Chair: G. K. Wenning (Austria)
• Syncope and pseudosyncope – J.G. Van Dijk (Netherlands)
• EBM treatment of orthostatic hypotension and related symptoms – G.K. Wenning (Austria)
• Evaluation forms and concluding remarks

Chair(s): Stefan Meng (Austria)

• Welcome and basic anatomy and intervention tactics
• Nerve Part 1.1: Hands-on Ultrasound assessment of local, perineural anatomy
• Nerve Part 1.2: Ultrasound guided injections in anatomic specimen
• Muscle: Practical muscle botulinum toxin injection course – Daniel Truong (USA)
• Nerve Part 2.1: Inspections of prepared specimens from Nerve Part 1: anatomical topology, injection fluid distribution
• Nerve Part 2.2: New nerve ultrasound injections in anatomic specimen

Chair(s): TBD

I) Peripheral autonomic neuropathies
• Diabetic autonomic neuropathy - R. Freeman (USA)
• Autonomic Dysfunction in GBS - M. Hilz (Germany)
• Autonomic autoantibodies: What are they doing, which need to be assessed, how do we treat - TBD
• ANS and Amyloid - I. Rocha (Portugal)

II) Neurodegeneration & ANS
• PAF-MSA-Parkinson how to differentiate, how to confuse, similarities and specifics - G. Wenning (Austria)
• Links from periphery to the brain - A. Fanciulli (Austria)
• Sleep disorders & ANS - P. Cortelli (Italy)
• Autonomic Dysfunction in Dementia - W. Struhal (Austria)

III) TLOC, Brain injury and ANS sequelae
• Differential diagnosis - J.G. van Dijk (Netherlands)
• Autonomic Dysfunction in epilepsy - R. Thijs (Netherlands)
• Stroke and ANS - M. Hilz (Germany)
• Syncopedia training a new generation of syncope specialist - J de Jong (Netherlands)

IV) Autonomic Nervous system and Fatigue Background and Management
• Autonomic nervous system in simulated and real weightlessness - A. Pavy-Le Traon (France)
• Prognostic autonomic biomarkers - J.M. Senard (France)
• Fatigue and autonomic nervous system dysfunction in people with multiple sclerosis - M. Habek (Croatia)
• Gastric dysfunction - H. Zoller (Austria)

Chair(s):

• PL 1.1: Pathomechanisms - Volker Straub (UK)
• PL 1.2: Inflammatory mechanisms - Andrew Mammen (USA)
• PL 1.3: Genetics / Epigenetics - Hanns Lochmüller (Germany)

Chair(s): Marianne de Visser (Netherlands)

• Treatment strategies in GNE myopathy - Zohar Argov (Israel)
• Genome editing for monogenic myopathies - TBD
• Progress in the treatment of idiopathic inflammatory myopathies? - Marianne de Visser (Netherlands)

Chair(s): Anthony Windebank (USA)

• Tissue Engineering Strategies for Repair of Peripheral Nerve - Anthony Windebank (USA)
• Use of physical methods in nerve regeneration - Thomas Hausner (Austria)
• New developments in conduits – David Hercher (Austria)

Chair(s): Bruno Giometto (Italy)

• The role of HU proteins in the development of paraneoplastic neuropathies - Bruno Giometto (Italy)
• Physiopathology of paraneoplastic ganglionopathies - Romana Hoeftberger (Austria)
• Paraneoplastic muscle disorders - Andrew Mammen (USA)
• Lambert-Eaton-Syndrome (LEMS) - Jan Verschuuren (Netherlands)

Chair(s): Antonio Toscano (Italy)

• Update on clinical aspects of Glycogen storage disorders - Antonio Toscano (Italy)
• Novel entities in congenital myopathies of adult onset - Baziel van Engelen (Netherlands)
• New phenotypes in titin defects - Bjarne Udd (Finland)

Chair(s): Tatjana Paternostro-Sluga (Austria)

• Chemotherapy induced PNP - Anthony Windebank (USA)
• Iatrogenic mononeuropathies after surgery and trauma - Tatjana Paternostro-Sluga (Austria)
• Case Report - TBD

Chair(s): Günther Bernert (Austria) , James Dowling (Canada)

• Introduction: Standards of Care: what we have learned from long term-management in children with NMD's - Günther Bernert (Austria)
• Future of AAV-based gene therapy approaches for NMDs - Thomas Voit (UK)
• New Treatments in Paediatric NMD's: Fake or Fact? - Eugenio Mercuri (Italy)
• Transition from paediatric into adult care: a long way to go? - Thomas Serjensen (Sweden)

Chair(s): Zohar Argov (Israel) , Maya Zatz (Brazil)

• Stem cells as tools for research and therapy in neuromuscular disorders - Rita Perlingeiro (USA)
• Stem cells in muscular dystrophies - Mayana Zatz (Brazil)
• Stem cells in ALS - Dimitrios Karussis (Israel)

Chair(s): Ahmet Hoke (USA) , Guido Cavaletti (Italy)

• General principles/clinical aspects - Nathan Staff (USA)
• Basic mechanisms: Axonal degeneration and chemotherapy-induced peripheral neuropathy - Ahmet Hoke (USA)
• Animal models of chemotherapy-induced peripheral neuropathy - Guido Cavaletti (Italy)

Chair(s): Georg Padberg (Netherlands)

• DUX4, its role in development and muscle disease - Stephen Tapscott (USA)
• Trials readiness in FSHD: clinical, imaging and other biomarkers - Jeffrey Statland (USA)
• FSHD's changing landscape and future perspectives - Georg Padberg (Netherlands)

Chair(s): David Oliver (UK)

• The role of palliative care – early involvement or end of life care? - David Oliver (UK)
• The role of the multidisciplinary team in NMD – the evidence from ALS - Christopher McDermott (UK)
• The recognition of the end of life phase in NMD – the support of patients, families and professionals - Stefan Lorenzl (Austria)
• Integrating palliative care into service for ALS patients: experiences from Russia - Lev Brylev (Russia)

Chair(s): Anthony Amato (USA)

• Update on Histopathological Features of Inflammatory Myopathies - Anthony Amato (USA)
• Update on Myositis Specific Autoantibodies - Discussion on utility of MSAs in diagnosis and prognosis - Andrew Mammen (USA)
• Update on Utility of Skeletal Muscle MRI and Ultrasound - Jasper M. Morrow (UK)

Chair(s): TBD

Chair(s): TBD

• PL 2.1: Inherited neuropathies: from genes to clinical phenotype - Mary Reilly (UK)
• PL 2.2: Immune mediated neuropathies: an expanding field of treatable neuropathies - Peter van Doorn (Netherlands)
• PL 2.3: Advances in the treatment of peripheral neuropathy - David Cornblath (USA)

Chair(s): TBD

• New genes and new mechanisms in inherited neuropathies - Vincent Timmermann (Belgium)
• Therapeutic options in CMT - Michael Sereda (Germany)
• Familial amyloid neuropathies: a treatable genetic neuropathy - Davide Pareyson (Italy)

Chair(s): Wolfgang Grisold (Austria)

• Cranial nerves: within and out of the skull, incl. Angiosoma - Wolfgang Grisold (Austria)
• Infectious and Inflammatory Cranial nerve lesions - Nazha Birouk (Morocco)
• Painful cranial nerve lesions - Frank Thömke (Germany)
• Paroxysmal dysfunctions - Friedrich Zimprich (Austria)

Chair(s): TBD

• The autonomic view - Gregor Wenning (Austria)
• The neuromuscular view - Walter Struhal (Austria)
• Discussion

• The autonomic view - Max Hilz (Germany)
• Suggested Speaker ICNMD - Michael Auer-Grumbach (Austria)
• Discussion

• The autonomic view: Roy Freeman (USA)
• Suggested Speaker ICNMD: Paola Sandroni (USA)
• Discussion

Chair(s): Eva Feldman (USA)

• 2017 ADA Position Statement on Diabetic Neuropathy: Does it change your practice? - Vera Bril (Canada)
• Scientific Discovery Leads to Clinical Trials in Diabetic Neuropathy - James Russell (USA)
• Painful Diabetic Neuropathy: A Management Centered Approach - Eva Feldman (USA)

Chair(s): TBD

• Diagnosis and treatment of CIDP: lesson from the databases - Eduardo Nobile-Orazio (Italy)
• Paraproteinemic neuropathies: when and how to treat - Jean-Marc Léger (France)
• POEMS syndrome: from diagnosis to therapy - Michelle Mauermann (USA)

Chair(s): Stefan Meng (Austria)

• Ultrasound in Cranial Nerves - Stefan Meng (Austria)
• Clinical and microsurgical significance of cranial nerve visualization - Andres Rodriguez (Sweden)
• High resolution MRI of cranial nerves - Jennifer Kollmer (Germany)

Chair(s): Kathy Oliver (UK)

• James Lind Alliance Priority Setting Partnership in Neuro-Oncology (research priorities) - Kathy Oliver (UK)
• Approach to Patient-Centered Outcomes Research - Richard Barohn (USA)
• The Patient Voice in Myasthenia Gravis Trials- PCORI, CER, and more alphabet soup - Pushpa Narayanaswami (USA)
• How can outcomes of clinical studies be translated for patients - Angela Genge (Canada)

Chair(s): Zohar Argov (Israel)

• Neuromuscular disorders with dysphagia: an outline - Marianne de Visser (Netherlands)
• How to assess and manage dysphagia - Zohar Argov (Israel)
• Ethical issues in dysphagia treatments - David Oliver (UK)

Chair(s): TBD

• Pathophysiology of the Node of Ranvier - Antonino Uncini (Italy)
• New pathogenetic mechanisms underlying immune neuropathies - Hugh Willison (UK)
• Antibodies to the node of Ranvier in CIDP: a new clue to therapy - Louis Querol (Spain)

Chair(s): Wolfgang Grisold (Austria)

• Cachexia and late effects of cancer - Ioannis Gioulbasanis (Greece)
• Sarcopenia - Alan Pestronk (USA)
• Outline on myopathies / neuromuscular complications associated with cancer, incl. steroid myopathy - Anthony Amato (USA)
• Cancer rehabilitation - TBD

Chair(s): Andreas Steck (Switzerland)

• Spectrum of paraproteinemic neuropathies - Eduardo Nobile-Orazio (Italy)
• Anti-MAG neuropathy: current and novel treatments - Andreas Steck (Switzerland)
• Creating proper outcome measures - Ingemar Merkies (Netherlands)

Chair(s): George Padberg (Netherlands), Baziel van Engelen (Netherlands)

• Introduction about the ENMC - Ellen Sterrenburg (Netherlands)
• Why opt for an ENMC workshop? - George Padberg (Netherlands) & Baziel van Engelen (Netherlands)
• The impact of 25 years ENMC workshops - Raffaella Willmann (Switzerland)
• Charcot-Marie-Tooth Disease at ENMC workshops - Mary Reilly (UK)
• Translational research workshop - Kanneboyina Nagaraju (USA)
• Management of ventilation problems in patients with neuromuscular conditions - Michel Toussaint (Belgium)
• The position of neuromuscular patients in Shared Decision Making - Anna Ambrosini (Italy)
• Questions and conclusion of the ENMC symposium- George Padberg (Netherlands)

Chair(s): TBD

Chair(s): TBD

• PL 3.1: Emerging therapies for Motor Neurone Diseases - Albert Ludolph (Germany)
• PL 3.2: Clinical concept of ALS - Leonard Van den Berg (Netherlands)
• PL 3.3: Ethical issues - David Oliver (UK)

Chair(s): Albert Ludolph (Germany)

• Overview – drug treatment for SMA - Janbernd Kirschner (Germany)
• Treatments to improve survival of motor neurons - Albert Ludolph (Germany)
• Splicing modification for SMA - Nathalie Goemans (Belgium)
• Gene therapy for SMA - Arthur Burghes (USA)

Chair(s): Stefan Meng (Austria)

• MR Neurography: New approaches and techniques for diagnosing mononeuropathies - Jennifer Kollmer (Germany)
• New ultrasensitive Ultrasound methods - Stefan Meng (Austria)
• OCT - Wolfgang Drexler (Austria)

Chair(s): David Bennett (UK)

• Changes in the nodal complex in painful neuropathy - Claudia Sommer (Germany)
• The use of nerve excitability testing in understanding ion channel dysfunction in neuropathy - Matthew Kiernan (Australia)
• Human pain channelopathies - David Bennett (UK)

Chair(s): Marianne de Visser (Netherlands)

• NIV and ALS - Marianne de Visser (Netherlands)
• Nutrition and ALS - Esther Hobson (UK)
• Nutrition NIV and cognition in ALS - Vincenzo Silani (Italy)

Chair(s): Wolfgang Grisold (Austria)

• Neurofibromatosis - Katharina Wimmer (Austria)
• Peripheral nerve tumors - Gelareh Zadeh (Canada)
• Perineuroma - Michelle Mauermann (USA)
• Cancer and peripheral nerves - Wolfgang Grisold (Austria)

Chair(s): Thomas Hausner (Austria)

• Nerve fibre transfer versus nerve reconstruction - Robert Schmidhammer (Austria)
• Nerve regeneration - Ahmet Hoke (USA)
• Brain plasticity in nerve regeneration - Thomas Hausner (USA)

Chair(s): Matthew Kiernan (Australia) , Alan Pestronk (USA)

• MND: Therapeutic landscapes - Matthew Kiernan (Australia)
• Treatment Strategies for Hereditary ALS - Tim Miller (USA)
• Diagnosis and Treatment of Motor neuropathies - Alan Pestronk (USA)

Chair(s): Zohar Argov (Austria) , Corrado Angelini (Italy)

• Impact and evolution of cognitive impairment in muscular dystrophies - Corrado Angelini (Italy)
• Brain imaging techniques for the neuromuscular patients - Nicola de Stefano (Italy)
• The gap between cognitive assessment and brain imaging: lessons from DMD - Nathalie Doorenweerd (Netherlands)

Chair(s): Davide Pareyson (Italy)

• How Transthyretin becomes toxic - Laura Obici (Italy)
• Challenges in diagnosing and monitoring ATTR amyloidosis - Davide Pareyson (Italy)
• The novel scenario of ATTR amyloidosis treatment - Teresa Coelho (Portugal)

Chair(s): Steven Lewis (USA)

• Vitamin deficiencies and neuropathy - Carrie Grouse (USA)
• Mineral deficiencies and neuropathy - Steven Lewis (USA)
• Vitamin and mineral toxicities and neuropathy - Nathan Staff (USA)

Chair(s): Wolfgang Löscher (Austria)

• Distal hereditary motor neuropathies (dHMN) - Mary Reilly (UK)
• Distal Myopathies - Anthony Amato (USA)
• Acquired distal motor syndromes - Matthew Kiernan (Australia)

Chair(s): Orla Hardiman (Ireland)

• Multidisciplinary Clinics- What is the evidence and how can we do better? - Leonard van den Berg (Netherlands)
• Measurement of disease progression, Can we do better? - Orla Hardiman (Ireland)
• Rehabilitation Interventions that change outcome in ALS/MND - TBD

Chair(s): Wolfgang Grisold (Austria)

• Cranial nerves - Wolfgang Grisold (Austria)
• Peripheral nerve lymphoma - James Dyck (USA)
• Cancer-associated Myositis - Yves Allenbach(France)

Chair(s): TBD

Chair(s): TBD

• PL 4.1: Physiology and structure - Steve Burden (USA)
• PL 4.2: Congenital Myasthenic Syndromes - New genes and better treatments / antibodies - Kinji Ohno (Japan)
• PL 4.3: Autoimmunity - Angela Vincent (UK)

Chair(s): Gil Wolfe (USA)

• Evolution of monoclonal Ab treatment approaches in MG - Ted Burns (USA)
• Other novel treatment approaches: 3, 4 DAP, alpha fetoprotein, exercise - Anna Punga (Sweden)
• Overview of treatment guidelines: going forward - Gil Wolfe (USA)

Chair(s): John England (USA)

• Neurological complications of Zika virus - John England (USA)
• Leprous neuropathies - Gerard Said (France)
• Neuropathies in infectious diseases - Nazha Birouk (Morocco)
• Infection related Neuromuscular disorders (Neuropathies and Myopathies) - Chandrashekhar Meshram (India)

Chair(s): Sonja Horn (Austria)

• The history of neuromuscular diseases and their treatment in Habsburg countries - Sonja Horn (Austria)
• History on Myasthenia Gravis - Richard Barohn (USA)
• Andalusian Neurology over 700 years - Raad Shakir (UK)

Chair(s): Richard Barohn (USA)

• Overview of thymectomy in MG - Richard Barohn (USA)
• Randomized controlled trial of thymectomy: a deeper dive into data - Gil Wolfe (USA)
• Pathology of the thymus gland in MG - Alexander Marx (Germany)

Chair(s): Markus Rüegg (Switzerland)

• Molecular mechanisms affecting neuromuscular junction development and maintenance - Markus Rüegg (Switzerland)
• Salbutamol and Dok-7 as potential treatment options for neuromuscular disorders - David Beeson (UK)
• Sympathetic innervation of the neuromuscular junction; possible explanation for the therapeutic effect of sympathicomimetics in NMDs? - Rüdiger Rudolf (Germany)

Chair(s): Rolf Schröder (Germany) , Gerhard Wiche (Austria)

• Basics and what we are learning from mice - Gerhard Wiche (Austria)
• Human plectin and clinical aspects - Rolf Schröder (Germany)
• Plectin and mitochondria (mice and men) - Lilli Winter (Austria)
• Plectin, cardiomyopathies, and therapeutic approaches (mice) - Oliver Müller (Germany)

Chair(s): Corrado Angelini (Italy)

• The clinical phenotypes of calpainopathy - Andoni Urtizberea (France)
• Muscle pathology of LGMD - Kristen Claeys (Belgium)
• The advent of NGS in LGMD diagnosis - Vincenzo Nigro (Italy)
• Perspectives in clinical trials of recessive and dominant LGMD - Corrado Angelini (Italy)

Chair(s): Andreas Steck (Switzerland)

• Vasculitic Neuropathies (Rheumatoid Disorders) - Gerard Said (France)
• Statin Neuropathies - Hadi Manji (UK)
• MGUS associated peripheral neuropathy: diagnosis and treatment - Andreas Steck (Switzerland)

Chair(s): David Beeson (UK)

• Synaptic stability in CMS - David Beeson (UK)
• Recent presynaptic CMS - Hanns Lochmüller (UK)
• Clinical aspects of CMS - Hakan Cetin (Austria)
• Treatment for CMS - Jacqueline Palace (UK)

Chair(s): Nils Erik Gilhus (Norway)

• Autoantibodies in myasthenia gravis - Nils Erik Gilhus (Norway)
• Micro-RNA as a biomarker in myasthenia gravis - Anna Punga (Sweden)
• Thymus biomarkers and clinical relevance - Alexander Marx (Germany)

Chair(s): Monika Hofer (UK) , Rolf Schröder (Germany)

• Muscle biopsies - Rolf Schröder (Germany) & Monika Hofer (UK)
• Nerve biopsies - James Dyck (USA)
• Skin biopsies - Giuseppe Lauria (Italy)

Chair(s): Eva Feldman (USA)

• Diabetic cranial neuropathies - Tudor Lupescu (Romania)
• Musculoskeletal Complications of Diabetes are Common and Underdiagnosed - Anna Grisold (Austria)
• Atypical Neuropathies in Diabetes: Diagnosis and Management - Amanda Peltier (USA)
• Treatment Induced and Inflammatory Neuropathies in Diabetes - Brian Callaghan (USA)